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Article

Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age.

Neurobiology of aging - 1 Jan 2000

Cottrell D A, Blakely E L, Johnson M A, Ince P G, Borthwick G M, Turnbull D M

Abstract excerpt

The chronological accumulation of mitochondrial dysfunction has been proposed as a potential mechanism in the physiological processes of aging. Cytochrome c oxidase deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders. We show that there is an age-related increase in cytochrome c...

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PMID: 11182476
DOI: 10.1016/s0197-4580(00)00234-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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