Article
Temporal bone analysis of patients with presbycusis reveals high frequency of mitochondrial mutations.
Hearing research - 1 Aug 1997
Fischel-Ghodsian N, Bykhovskaya Y, Taylor K, Kahen T, Cantor R, Ehrenman K, Smith R, Keithley E
Abstract excerpt
Presbycusis is a histologically and genetically heterogenous group of disorders, which lead to progressive, primarily sensorineural hearing loss with aging. Acquired mitochondrial DNA defects have been proposed as important determinants of aging, particularly in neuro-muscular tissues. The spiral...
Topics
- Aged
- Aged, 80 and over
- Aging
- Child
- DNA, Mitochondrial
- Ear, Inner
- Electron Transport Complex IV
- Female
- Gene Expression Regulation, Enzymologic
- Humans
- Male
- Mutation