Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions.

Journal of molecular biology - 3 Aug 2001

Sissi C, Perdonà E, Domenici E, Feriani A, Howells A J, Maxwell A, Palumbo M

Abstract excerpt

The conformational equilibria of the A subunit of DNA gyrase (GyrA), of its 59 kDa N-terminal fragment (GyrA59) and of the quinolone-resistant Ser-Trp83 mutant (GyrATrp83), were investigated in the presence of mono- and divalent metal ions and ciprofloxacin, a clinically useful antibacterial quinolone. The stability of the proteins was estimated from temperature denaturation, monitoring unfolding with circular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Infective Agents
Share to Cations, Divalent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatography, Affinity

Share to Ciprofloxacin

Share to DNA Topoisomerases, Type II

Share to Magnesium

Share to Osmolar Concentration

Source

Identifiers

PMID: 11469868
DOI: 10.1006/jmbi.2001.4838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions.PMID 11469868Read ↗

Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87).Semantic proximity Read ↗

Metal ion-binding studies highlight important differences between flaviviral RNA polymerases.Semantic proximity Read ↗

Analysis of the NH2-terminal 83rd amino acid of Escherichia coli GyrA in quinolone-resistance.Semantic proximity Read ↗

Escherichia coli DNA gyrase: genetic analysis of gyrA and gyrB mutations responsible for thermosensitive enzyme activity.Semantic proximity Read ↗

Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones.Semantic proximity Read ↗

Interaction of nalidixic acid and ciprofloxacin with wild type and mutated quinolone-resistance-determining region of DNA gyrase A.Semantic proximity Read ↗

Structural and Computational Analysis of Pseudomonas aeruginosa DNA Gyrase Reveals Molecular Characteristics That May Contribute to Ciprofloxacin Resistance.Semantic proximity Read ↗

Ciprofloxacin binding to GyrA causes global changes in the proteome of Pseudomonas aeruginosa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.