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Article

Acute cardiac and hemodynamic effects of sildenafil on resistant hypertension.

European journal of clinical pharmacology - 1 Dec 2013

Quinaglia Thiago, de Faria Ana Paula C, Fontana Vanessa, Barbaro Natália R, Sabbatini Andréa R, Sertório Jonas T, Demacq Caroline, Tanus-Santos José E, Moreno Heitor

Abstract excerpt

PURPOSE: Failure to control blood pressure (BP) despite the use of three or more drugs characterizes resistant hypertension (RHTN). Impaired endothelial function is associated with this condition and phosphodiesterase-5 inhibitors (PDE5i)-inhibiting cGMP breakdown-reduce BP in RHTN patients. We hypothesized that acute administration of PDE5i could ameliorate hemodynamic, endothelial parameters and left...

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PMID: 23963046
DOI: 10.1007/s00228-013-1571-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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