Article

Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification

2018-05-11

Abstract excerpt

<h4>Summary</h4> Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus ; GAS) and Streptococcus mutans . Those pathogens require dTDP-L-rhamnose for the production of structurally similar rhamnose polysaccharides in their cell wall. Via heterologous expression in S. m...

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Literature Corpus work: 319c336d-3825-5571-a664-237efd9d7c41
DOI: 10.1101/312157

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