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Article

Profiling deleterious non-synonymous SNPs of smoker's gene CYP1A1.

Cell biochemistry and biophysics - 1 Jan 2013

Ramesh A Sai, Khan Imran, Farhan Md, Thiagarajan Padma

Abstract excerpt

CYP1A1 gene belongs to the cytochrome P450 family and is known better as smokers' gene due to its hyperactivation as a consequence of long term smoking. The expression of CYP1A1 induces polycyclic aromatic hydrocarbon production in the lungs, which when over expressed, is known to cause smoking related diseases, such as cardiovascular pathologies, cancer, and diabetes. Single nucleotide polymorphisms (SNPs) are...

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PMID: 23733671
DOI: 10.1007/s12013-013-9671-z

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