Article
Using linked markers to infer the age of a mutation.
Human mutation - 1 Aug 2001
Rannala B, Bertorelle G
Abstract excerpt
Advances in sequencing and genotyping technologies over the last decade have enabled geneticists to easily characterize genetic variation at the nucleotide level. Hundreds of genes harboring mutations associated with genetic disease have now been identified by positional cloning. Using variation at closely linked genetic markers, it is possible to predict the times in the past at which particular mutations arose....
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