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Impact of CYP2C19 Genotype on Sertraline and Escitalopram Exposure and Antidepressant Switching Rate: A Retrospective Cohort Study of Chinese Han Patients.

Clinical pharmacology and therapeutics - 1 Sept 2025

Yan Yuhang, Wang Jiaqi, Wang Donghan, Luan Yueyao, Sun Qixuan, Chen Chaoli, Lun Yang, Zhao Mengqiang, Su Shi, Yu Jing, Duan Liguang, Zhao Yuanyuan, Zhou Chunhua

Abstract excerpt

Sertraline and escitalopram, commonly used antidepressants in clinical practice, are metabolized by the polymorphic CYP2C19 enzyme. In a large-scale Chinese Han cohort, this study comprehensively examines the influence of CYP2C19 genotype on sertraline and escitalopram exposure, while also evaluating genotype-associated antidepressant switching rates. A total of 525 serum concentration measurements of sertraline...

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Identifiers

PMID: 40346857
DOI: 10.1002/cpt.3707

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CYP2C19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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