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Article

Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins.

Developmental biology - 1 Feb 2006

Eggenschwiler Jonathan T, Bulgakov Oleg V, Qin Jian, Li Tiansen, Anderson Kathryn V

Abstract excerpt

Sonic hedgehog (Shh) signaling is required for the growth and patterning of many tissues in vertebrate embryos, but important aspects of the Shh signal transduction pathway are poorly understood. For example, the vesicle transport protein Rab23 is a cell autonomous negative regulator of Shh signaling, but the process affected by Rab23 has not been defined. Here, we demonstrate that Rab23 acts upstream of Gli...

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Share to Cyclic AMP-Dependent Protein Kinases
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Patched Receptors

Share to rab GTP-Binding Proteins

Share to Smoothened Receptor

Share to Zinc Finger Protein Gli2

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Source

Identifiers

PMID: 16364285
DOI: 10.1016/j.ydbio.2005.09.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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