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Article

Redirection of sialic acid metabolism in genetically engineered Escherichia coli.

Glycobiology - 1 Jul 2001

Ringenberg M, Lichtensteiger C, Vimr E

Abstract excerpt

Most microorganisms do not produce sialic acid (sialate), and those that do appear to use a biosynthetic mechanism distinct from mammals. Genetic hybrids of nonpathogenic, sialate-negative laboratory Escherichia coli K-12 strains designed for the de novo synthesis of the polysialic acid capsule from E. coli K1 proved useful in elucidating the genetics and biochemistry of capsule biosynthesis. In this article we...

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PMID: 11447132
DOI: 10.1093/glycob/11.7.533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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