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Lipid aldehyde hydrophobicity affects apo-SOD1 modification and aggregation.

Free radical biology & medicine - 20 Aug 2020

Dantas Lucas S, Viviani Lucas G, Inague Alex, Piccirillo Erika, Rezende Leandro de, Ronsein Graziella E, Augusto Ohara, Medeiros Marisa H G, Amaral Antonia T do, Miyamoto Sayuri

Abstract excerpt

Unsaturated lipids are oxidized by reactive oxygen species and enzymes, leading to the increased formation of lipid hydroperoxides and several electrophilic products. Lipid-derived electrophiles can modify macromolecules, such as proteins, resulting in the loss of function and/or aggregation. The accumulation of Cu,Zn-superoxide dismutase (SOD1) aggregates has been associated with familial cases of amyotrophic...

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PMID: 32598986
DOI: 10.1016/j.freeradbiomed.2020.05.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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