Article
The effect of the Glu342Lys mutation in alpha1-antitrypsin on its structure, studied by molecular modelling methods.
Acta biochimica Polonica - 1 Jan 2001
Jezierski G, Pasenkiewicz-Gierula M
Abstract excerpt
The structure of native alpha1-antitrypsin, the most abundant protease inhibitor in human plasma, is characterised primarily by a reactive loop containing the centre of proteinase inhibition, and a beta-sheet composed of five strands. Mobility of the reactive loop is confined as a result of electrostatic interactions between side chains of Glu342 and Lys290, both located at the junction of the reactive loop and...
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