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Article

Sequence and chemistry requirements for a novel aptameric oligonucleotide inhibitor of EGF receptor tyrosine kinase activity.

Biochemical pharmacology - 15 Jun 2002

Akhtar Saghir, Dunnion Debbie, Poyner David, Ackroyd John, Bibby Mike, Double John

Abstract excerpt

We have previously identified a phosphorothioate oligonucleotide (PS-ODN) that inhibited epidermal growth factor receptor tyrosine kinase (TK) activity both in cell fractions and in intact A431 cells. Since ODN-based TK inhibitors may have anti-cancer applications and may also help understand the non-antisense mediated effects of PS-ODNs, we have further studied the sequence and chemistry requirements of the...

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Source

Identifiers

PMID: 12110378
DOI: 10.1016/s0006-2952(02)00985-1

Genes

CAT
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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