Article
Allosteric inhibitors of telomerase: oligonucleotide N3'-->P5' phosphoramidates.
Nucleic acids research - 15 Jan 2002
Pruzan Ronald, Pongracz Krisztina, Gietzen Kimberly, Wallweber Gerald, Gryaznov Sergei
Abstract excerpt
Telomerase is a ribonucleoprotein responsible for maintaining telomeres in nearly all eukaryotic cells. The enzyme is able to utilize a short segment of its RNA subunit as the template for the reverse transcription of d(TTAGGG) repeats onto the ends of human chromosomes. Transfection with telomerase was shown to confer immortality on several types of human cells. Moreover, telomerase activation appears to be one...
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