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Article

Long-range identification of hepatocyte nuclear factor-3 (FoxA) high and low-affinity binding sites with a chimeric nuclease.

Journal of molecular biology - 13 Jul 2001

Ruminy P, Derambure C, Chandrasegaran S, Salier J P

Abstract excerpt

Identifying the complete set of transcription factors that bind the promoter and other regulatory regions of a gene of interest is an essential step in functional genomics. We have developed an original assay for the systematic detection of hepatocyte nuclear factor-3 (HNF-3) binding sites within cloned promoters. This assay is based on expression of a recombinant enzyme, HNF-3beta/FN, that is comprised of the...

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PMID: 11439020
DOI: 10.1006/jmbi.2001.4788

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