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Article

Poor correlation between 6beta-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity.

British journal of clinical pharmacology - 1 Aug 2006

Chen Ya-Chi, Gotzkowsky S Karl, Nafziger Anne N, Kulawy Robert W, Rocci Mario L, Bertino Joseph S, Kashuba Angela D M

Abstract excerpt

AIMS: A non-invasive proposed method for measuring CYP3A activity is the urinary 6beta-hydroxycortisol:cortisol ratio. This ratio has been used as an indicator of CYP3A induction and inhibition, with mixed results. This investigation evaluated the relationship between a validated, biomarker, intravenous midazolam clearance and the urinary cortisol ratio under constitutive conditions and with the influence of a...

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Source

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Identifiers

PMID: 16842393
DOI: 10.1111/j.1365-2125.2006.02628.x
PMCID: PMC1885097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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