Article
Possible risk reduction in esophageal cancer associated with MPO -463 A allele.
Journal of epidemiology - 1 May 2001
Matsuo K, Hamajima N, Shinoda M, Hatooka S, Inoue M, Takezaki T, Onda H, Tajima K
Abstract excerpt
Myeloperoxidase (MPO), an enzyme found in lysosomes of phagocytes, causes hydroxy radicals linked to DNA damage and activation of smoking related carcinogens. A -463 G/A polymorphism in the promoter region of the MPO gene results in reduced gene expression, which would imply lower susceptibility of esophageal cancer in mutant carriers. We conducted case-control study to test this hypothesis. Cases were 91...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.