Article
Histone acetyltransferase complexes can mediate transcriptional activation by the major glucocorticoid receptor activation domain.
Molecular and cellular biology - 1 Sept 1999
Wallberg A E, Neely K E, Gustafsson J A, Workman J L, Wright A P, Grant P A
Abstract excerpt
Previous studies have shown that the Ada adapter proteins are important for glucocorticoid receptor (GR)-mediated gene activation in yeast. The N-terminal transactivation domain of GR, tau1, is dependent upon Ada2, Ada3, and Gcn5 for transactivation in vitro and in vivo. Using in vitro techniques, we demonstrate that the GR-tau1 interacts directly with the native Ada containing histone acetyltransferase (HAT)...
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