Article
Heterogeneity of the CYP2D6 gene among Malays in Malaysia.
Journal of clinical pharmacy and therapeutics - 1 Jun 2001
Teh L K, Ismail R, Yusoff R, Hussein A, Isa M N, Rahman A R
Abstract excerpt
BACKGROUND: Although Malays shared an origin with Chinese, their evolution saw substantial divergences. Phenotyping studies suggested that they differed in CYP2D6 polymorphism, with higher PM prevalence but lesser right-shift for debrisoquine MRs. OBJECTIVE: To study the genotype distribution of CYP2D6 among the Malays in Malaysia. METHOD: We obtained DNA from 107 Malays and used PCR to determine common CYP2D6...
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