Genetic correlations between initial sensitivity to Ethanol and brain cAMP signaling in inbred and selectively bred mice.

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Article

Genetic correlations between initial sensitivity to Ethanol and brain cAMP signaling in inbred and selectively bred mice.

Alcoholism, clinical and experimental research - 1 Jun 2001

Kirstein S L, Tabakoff B

Abstract excerpt

BACKGROUND: Several lines of evidence have suggested a role for cAMP (adenosine 3',5'-cyclic monophosphate) signaling in the acute and chronic effects of ethanol. This study investigated whether there is a genetic correlation between cAMP synthesis in the brain and the acute effects of ethanol [alcohol sensitivity or acute functional tolerance (AFT)]. METHODS: By using nine inbred strains of mice, we measured...

Topics

Animals
Brain
Cerebellum
Colforsin
Cyclic AMP
Ethanol
Genotype
Isoproterenol
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Inbred Strains
Signal Transduction
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 11410712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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