Article
Genetic correlations between initial sensitivity to Ethanol and brain cAMP signaling in inbred and selectively bred mice.
Alcoholism, clinical and experimental research - 1 Jun 2001
Kirstein S L, Tabakoff B
Abstract excerpt
BACKGROUND: Several lines of evidence have suggested a role for cAMP (adenosine 3',5'-cyclic monophosphate) signaling in the acute and chronic effects of ethanol. This study investigated whether there is a genetic correlation between cAMP synthesis in the brain and the acute effects of ethanol [alcohol sensitivity or acute functional tolerance (AFT)]. METHODS: By using nine inbred strains of mice, we measured...
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