Article
Normal apoptosis levels in mice expressing one alpha7 nicotinic receptor null and one L250T mutant allele.
Neuroreport - 13 Jun 2001
Broide R S, Orr-Urtreger A, Patrick J W
Abstract excerpt
The alpha7 nicotinic receptor (nAChR) is a ligand-gated ion channel mediating cholinergic transmission throughout the nervous system. To further characterize the function of this receptor, we generated mice expressing the alpha7 L250T nAChR mutation and demonstrated that homozygous (T/T) L250T mice die within 24 h of birth and display extensive apoptosis and abnormal layering within their cortex. We now...
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