Article
Systematic screening for mutations in the glycine receptor alpha2 subunit gene (GLRA2) in patients with schizophrenia and other psychiatric diseases.
Psychiatric genetics - 1 Mar 2001
Feng J, Craddock N, Jones I R, Cook E H, Goldman D, Heston L L, Peltonen L, DeLisi L E, Sommer S S
Abstract excerpt
The glycine receptor, which is a member of the ligand-gated ion channel superfamily, mediates synaptic inhibition in the spinal cord and other brain regions. This superfamily has been implicated in the pathogenesis of schizophrenia and other psychiatric diseases. The complete coding sequence and splice junctions of the GLRA2 gene were scanned by DOVAM-S, a form of SSCP analysis with sufficient redundancy to...
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