Article
Ordering genes in a flagella pathway by analysis of expression kinetics from living bacteria.
Science (New York, N.Y.) - 15 Jun 2001
Kalir S, McClure J, Pabbaraju K, Southward C, Ronen M, Leibler S, Surette M G, Alon U
Abstract excerpt
The recent advances in large-scale monitoring of gene expression raise the challenge of mapping systems on the basis of kinetic expression data in living cells. To address this, we measured promoter activity in the flagellar system of Escherichia coli at high accuracy and temporal resolution by means of reporter plasmids. The genes in the pathway were ordered by analysis algorithms without dependence on mutant...
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