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Article

Rottlerin induces a transformed phenotype in human keratinocytes.

Biochemical and biophysical research communications - 30 Mar 2001

Dietrich C, Gumpert N, Heit I, Borchert-Stuhlträger M, Oesch F, Wieser R

Abstract excerpt

PKCdelta plays a fundamental role in cell cycle control. Consistent with its proposed tumour suppressor function, ras transfection of the human keratinocyte cell line HaCaT results in a loss of PKCdelta expression mediated by TGFalpha (Exp. Cell Res., 219, 299, 1995). To get more insight into the role of PKCdelta in keratinocytes, we investigated the effects of Rottlerin, a specific inhibitor of protein kinase...

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Identifiers

PMID: 11401499
DOI: 10.1006/bbrc.2001.4530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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