Article
Alpha-fetoprotein structure and function: relevance to isoforms, epitopes, and conformational variants.
Experimental biology and medicine (Maywood, N.J.) - 1 May 2001
Mizejewski G J
Abstract excerpt
Mammalian alpha-fetoprotein (AFP) is classified as a member of the albuminoid gene superfamily consisting of albumin, AFP, vitamin D (Gc) protein, and alpha-albumin. Molecular variants of AFP have long been reported in the biomedical literature. Early studies identified isoelectric pH isoforms and lectin-binding variants of AFP, which differed in their physicochemical properties, but not in amino acid...
Topics
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Carbohydrates
- Cell Adhesion
- Cell Adhesion Molecules
- Epitope Mapping
- Epitopes
- Female
- Gene Expression Regulation
- Genetic Diseases, Inborn
- Genetic Variation
- Growth Substances
- Humans
- Hydrogen-Ion Concentration
- Immune Tolerance
- Maternal-Fetal Exchange
- Molecular Chaperones
