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Article

Structures of disease-specific serum alpha-fetoprotein isoforms

1 Nov 2000

Abstract excerpt

Alpha-fetoprotein (AFP) is widely used as a serological marker in the diagnosis of hepatocellular carcinoma (HCC) and non-seminomatous germ cell tumours (NSGCT). By application of isoelectric focusing (IEF) disease-specific AFP isoforms can be identified. Three major bands are apparent: + 1 (associated with 'benign' liver disease), + II (associated with HCC) and +III (associated with NSGCT). Recently, we have...

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PMID: 11044358
DOI: 10.1054/bjoc.2000.1441

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