Article
Is there a physiological role for gonadotrophin oligosaccharide heterogeneity in humans? III. Luteinizing hormone heterogeneity: a medical physiologist's perspective.
Human reproduction (Oxford, England) - 1 Jun 2001
Bergendah M, Veldhuis J D
Abstract excerpt
Clinical evidence for a physiological impact of luteinizing hormone (LH) isoforms includes their unequal in-vitro bioactivity and altered in-vivo LH kinetics. For example, alkaline LH isospecies emerge in an oestrogen-rich milieu, and show greater bioactivity in vitro along with more rapid metabolic removal in vivo. More acidic LH isotypes are predominant in eugonadal men with end-stage renal failure and in...
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