Article
Simvastatin exerts both anti-inflammatory and cardioprotective effects in apolipoprotein E-deficient mice.
Circulation - 29 May 2001
Scalia R, Gooszen M E, Jones S P, Hoffmeyer M, Rimmer D M, Trocha S D, Huang P L, Smith M B, Lefer A M, Lefer D J
Abstract excerpt
BACKGROUND: Simvastatin attenuates ischemia and reperfusion in normocholesterolemic animals by stabilizing endothelial nitric oxide synthase activity and inhibiting neutrophil-mediated injury. Because endothelial dysfunction is a detrimental effect of hypercholesterolemia, we examined whether short-term treatment with simvastatin could inhibit leukocyte-endothelium interaction and attenuate myocardial...
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