Article
Correlation of the 4977 bp mitochondrial DNA deletion with human sperm dysfunction
1 Jan 2009
Abstract excerpt
BACKGROUND: Several studies have examined the association between mitochondrial DNA (mtDNA) deletions, in particular the "common" 4977-bp deletion, and human sperm dysfunction, but have produced contradictory results. FINDINGS: Here we show that PCR slippage and primer miss-match to nuclear DNA may lead to overestimates in the frequency of deletions. Our investigation resolves this issue and gives strong negative...
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