Article
Sodium nitroprusside induces apoptosis of H9C2 cardiac muscle cells in a c-Jun N-terminal kinase-dependent manner.
International immunopharmacology - 1 May 2001
Chae H J, So H S, Chae S W, Park J S, Kim M S, Oh J M, Chung Y T, Yang S H, Jeong E T, Kim H M, Park R K, Kim H R
Abstract excerpt
Sodium nitroprusside (SNP) induces apoptosis in H9C2 cardiac muscle cells. Treatment with an exogenous NO donor SNP (2 mM) to H9C2 cells resulted in apoptotic morphological changes; a bright blue-fluorescent condensed nuclei and chromatin fragmentation by fluorescence microscope of Hoechst 33258-staining. The activity of caspase-3 like protease was increased during SNP-induced cell death. However, the activity of...
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