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Article

Different host-cell shutoff strategies related to the matrix protein lead to persistence of vesicular stomatitis virus mutants on fibroblast cells.

Virus research - 1 Jul 2001

Desforges M, Charron J, Bérard S, Beausoleil S, Stojdl D F, Despars G, Laverdière B, Bell J C, Talbot P J, Stanners C P, Poliquin L

Abstract excerpt

Acute infection of fibroblastic cell lines by the Indiana strain of vesicular stomatitis virus (VSV) usually induces dramatic cytopathic effects and shutoff of cellular gene expression. We have compared a series of independent mutants with differences in shutoff induction and found that M was mutated either in the N-terminus (M(51)R) or C-terminus (V(221)F and S(226)R). Furthermore, only double mutants (M...

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PMID: 11376849
DOI: 10.1016/s0168-1702(01)00251-9

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CPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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