Article
Matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus.
Virology - 30 Mar 2002
Desforges Marc, Despars Geneviève, Bérard Stéphane, Gosselin Myriam, McKenzie Margie O, Lyles Douglas S, Talbot Pierre J, Poliquin Laurent
Abstract excerpt
In a model system to study factors involved in the establishment of a persistent viral infection that may lead to neurodegenerative diseases, Indiana and New Jersey variants of vesicular stomatitis virus (VSV) with different capacities to infect and persist in human neural cells were studied. Indiana matrix (M) protein mutants and the wild-type New Jersey strain persisted in the human neural cell line H4 for at...
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