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Heterogeneous Nuclear Ribonucleoproteins C1 and C2 Associate with the RNA Component of Human Telomerase

1 Dec 2000

Abstract excerpt

Here we demonstrate that heterogeneous nuclear ribonucleoproteins (hnRNPs) C1 and C2 can associate directly with the integral RNA component of mammalian telomerase. The binding site for hnRNPs C1 and C2 maps to a 6-base uridylate tract located directly 5' to the template region in the human telomerase RNA (TR) and a 4-base uridylate tract directly 3' to the template in the mouse TR. Telomerase activity is...

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Share to RNA Interference and Gene Delivery
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Share to Telomeres, Telomerase, and Senescence

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PMID: 11074006
DOI: 10.1128/mcb.20.23.9084-9091.2000

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