Article
The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels.
Proceedings of the National Academy of Sciences of the United States of America - 9 Aug 2005
Cantí C, Nieto-Rostro M, Foucault I, Heblich F, Wratten J, Richards M W, Hendrich J, Douglas L, Page K M, Davies A, Dolphin A C
Abstract excerpt
All auxiliary alpha2delta subunits of voltage-gated Ca2+ (Ca(V)) channels contain an extracellular Von Willebrand factor-A (VWA) domain that, in alpha2delta-1 and -2, has a perfect metal-ion-dependent adhesion site (MIDAS). Modeling of the alpha2delta-2 VWA domain shows it to be highly likely to bind a divalent cation. Mutating the three key MIDAS residues responsible for divalent cation binding resulted in a...
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