Article
A role for selection in regulating the evolutionary emergence of disease-causing and other coding CAG repeats in humans and mice.
Molecular biology and evolution - 1 Jun 2001
Hancock J M, Worthey E A, Santibáñez-Koref M F
Abstract excerpt
The evolutionary expansion of CAG repeats in human triplet expansion disease genes is intriguing because of their deleterious phenotype. In the past, this expansion has been suggested to reflect a broad genomewide expansion of repeats, which would imply that mutational and evolutionary processes acting on repeats differ between species. Here, we tested this hypothesis by analyzing repeat- and flanking-sequence...
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