Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation patterns of amino acid tandem repeats in the human proteome.

Genome biology - 1 Jan 2006

Mularoni Loris, Guigó Roderic, Albà M Mar

Abstract excerpt

BACKGROUND: Amino acid tandem repeats are found in nearly one-fifth of human proteins. Abnormal expansion of these regions is associated with several human disorders. To gain further insight into the mutational mechanisms that operate in this type of sequence, we have analyzed a large number of mutation variants derived from human expressed sequence tags (ESTs). RESULTS: We identified 137 polymorphic variants in...

Topics

Amino Acid Substitution
Codon
Expressed Sequence Tags
Humans
Mutation
Polymorphism, Genetic
Proteome
Repetitive Sequences, Amino Acid
Sequence Analysis, Protein

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 16640792
DOI: 10.1186/gb-2006-7-4-r33
PMCID: PMC1557989

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation patterns of amino acid tandem repeats in the human proteome.PMID 16640792Read ↗

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general populationSemantic proximity Read ↗

Genome-wide survey of tandem repeats by nanopore sequencing shows that disease-associated repeats are more polymorphic in the general population.Semantic proximity Read ↗

Genome-wide Survey of Tandem Repeats by Nanopore Sequencing Shows that Disease-associated Repeats are More Polymorphic in the General PopulationSemantic proximity Read ↗

A comprehensive tandem repeat catalog of the human genomeSemantic proximity Read ↗

TRPing up the genome: Tandem repeat polymorphisms as dynamic sources of genetic variability in health and disease.Semantic proximity Read ↗

Tandem repeat copy-number variation in protein-coding regions of human genes.Semantic proximity Read ↗

Robust detection of tandem repeat expansions from long DNA readsSemantic proximity Read ↗

Tandem repeat polymorphisms: Mediators of genetic plasticity, modulators of biological diversity and dynamic sources of disease susceptibility.Semantic proximity Read ↗

Microsatellite expansions hidden within the human dark genome are translated in novel and toxic proteins causing muscle and neurodegenerative diseasesSemantic proximity Read ↗

Non-random distribution of homo-repeats: links with biological functions and human diseases.Semantic proximity Read ↗

TRbase: a database relating tandem repeats to disease genes for the human genome.Semantic proximity Read ↗

Large scale in silico characterization of repeat expansion variation in human genomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.