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Article

Post-translational modification of the myxoma-virus anti-inflammatory serpin SERP-1 by a virally encoded sialyltransferase.

The Biochemical journal - 15 Apr 2000

Nash P, Barry M, Seet B T, Veugelers K, Hota S, Heger J, Hodgkinson C, Graham K, Jackson R J, McFadden G

Abstract excerpt

SERP-1 is a secreted serpin (serine-proteinase inhibitor) encoded by myxoma virus, a poxvirus pathogen of rabbits. SERP-1 is required for myxoma-virus virulence, and the purified protein has been shown to possess independent anti-inflammatory activity in animal models of restenosis and antigen-induced arthritis. As an inhibitor of serine proteinases, SERP-1 acts against tissue-type plasminogen activator,...

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Identifiers

PMID: 10749666
DOI: 10.1042/0264-6021:3470375
PMCID: PMC1220969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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