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Article

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription

28 Jan 2013

Abstract excerpt

We previously established that besides its canonical function as E3-ubiquitin ligase, parkin also behaves as a transcriptional repressor of p53. Here we show that parkin differently modulates presenilin-1 and presenilin-2 expression and functions at transcriptional level. Thus, parkin enhances/reduces the protein expression, promoter activity and mRNA levels of presenilin-1 and presenilin-2, respectively, in...

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PMID: 23359614
DOI: 10.1093/jmcb/mjt003

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