Article
Lack of association between androgen receptor CAG polymorphism and familial breast/ovarian cancer.
Cancer letters - 10 Jul 2001
Menin C, Banna G L, De Salvo G, Lazzarotto V, De Nicolo A, Agata S, Montagna M, Sordi G, Nicoletto O, Chieco-Bianchi L, D'Andrea E
Abstract excerpt
The human androgen receptor (AR) gene contains a highly polymorphic CAG repeat in exon 1 that is inversely correlated with AR transcriptional activity in vitro. Several studies have shown that fewer CAG repeats are associated with an increased risk as well as more aggressive forms of prostate cancer. More recently, AR allele length was also inversely correlated with the histological grade of breast cancer, but no...
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