Article
The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Breast cancer research : BCR - 1 Jan 2005
Spurdle Amanda B, Antoniou Antonis C, Duffy David L, Pandeya Nirmala, Kelemen Livia, Chen Xiaoqing, Peock Susan, Cook Margaret R, Smith Paula L, Purdie David M, Newman Beth, Dite Gillian S, Apicella Carmel, Southey Melissa C, Giles Graham G, Hopper John L, Chenevix-Trench Georgia, Easton Douglas F
Abstract excerpt
INTRODUCTION: The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9-32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have been reported to have an earlier age at onset of breast cancer. METHODS: A total of 604 living female Australian and British BRCA1 and/or BRCA2 mutation carriers from 376 families were genotyped for the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.