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Article

The folding of alpha-1-proteinase inhibitor: kinetic vs equilibrium control.

Archives of biochemistry and biophysics - 15 Jan 2001

Tran S T, Shrake A

Abstract excerpt

Previous folding studies of alpha-1-proteinase inhibitor (alpha1-PI), which regulates the activity of the serine protease human neutrophil elastase, show an intermediate state at approximately 1.5 M guanidine-HCl (Gu). For the normal form of alpha1-PI, we demonstrate the reversible formation of t...

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Identifiers

PMID: 11368013
DOI: 10.1006/abbi.2000.2186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-11368013-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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