Inhibitory activity and conformational transition of alpha 1-proteinase inhibitor variants.

doi:10.1111/j.1432-1033.1991.tb16483.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Inhibitory activity and conformational transition of alpha 1-proteinase inhibitor variants.

European journal of biochemistry - 18 Dec 1991

Schulze A J, Huber R, Degryse E, Speck D, Bischoff R

Abstract excerpt

Several variants of alpha 1-proteinase inhibitor (alpha 1-PI) were investigated by spectroscopic methods and characterized according to their inhibitory activity. Replacement of Thr345 (P14) with Arg in alpha 1-PI containing an Arg residue in position 358 (yielding [Thr345----Arg, Met358----Arg]a...

Topics

Amino Acid Sequence
Chromatography, High Pressure Liquid
Chromosome Deletion
Circular Dichroism
Cloning, Molecular
Escherichia coli
Genetic Variation
Humans
Models, Structural
Molecular Sequence Data
Molecular Weight
Mutagenesis, Site-Directed
Protein Conformation
Sequence Homology, Nucleic Acid
Spectrometry, Fluorescence
Thrombin
alpha 1-Antitrypsin

Source

Open in PubMed

Identifiers

PMID: 1765073
DOI: 10.1111/j.1432-1033.1991.tb16483.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1765073-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics