Article
C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae.
International immunopharmacology - 1 Mar 2001
Ram S, Cullinane M, Blom A M, Gulati S, McQuillen D P, Boden R, Monks B G, O'Connell C, Elkins C, Pangburn M K, Dahlbäck B, Rice P A
Abstract excerpt
Screening of 29 strains of Neisseria gonorrhoeae revealed that 16/21 serum resistant strains and 0/8 serum sensitive strains bound C4bp, suggesting that C4bp binding to gonococci could contribute to serum resistance. C4bp bound to gonococci retained cofactor (C4b-degrading) function. Using allelic exchange to construct strains with hybrid Por1A/B molecules, we demonstrate that the N-terminal loop (loop 1) of...
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