CCR5 mutations and HIV susceptibility.

Abstract excerpt

Research has demonstrated that increased expression of CCR5 in monocytes/macrophages increases a person's susceptibility to HIV-1 infection. Activating macrophages by treatment with the cytokine GM-CSF appears to decrease susceptibility to HIV-1 infection by decreasing CCR5 expression. This may explain why HIV patients treated with GM-CSF appear to resist increased HIV-1 replication.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Disease Susceptibility
• Share to Genetic Predisposition to Disease
• Share to Granulocyte-Macrophage Colony-Stimulating Factor