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Article

Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.

The Journal of biological chemistry - 27 Jul 2001

Snyder P M, Olson D R, McDonald F J, Bucher D B

Abstract excerpt

The epithelial Na+ channel (ENaC) absorbs Na+ across the apical membrane of epithelia. The activity of ENaC is controlled by its interaction with Nedd4; mutations that disrupt this interaction increase Na+ absorption, causing an inherited form of hypertension (Liddle's syndrome). Nedd4 contains an N-terminal C2 domain, a C-terminal ubiquitin ligase domain, and multiple WW domains. The C2 domain is thought to be...

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Identifiers

PMID: 11359767
DOI: 10.1074/jbc.M011487200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.PMID 11359767Read ↗

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.Semantic proximity Read ↗

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel.Semantic proximity Read ↗

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Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.Semantic proximity Read ↗

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WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.Semantic proximity Read ↗

Characterization of interactions between Nedd4 and beta and gammaENaC using surface plasmon resonance.Semantic proximity Read ↗

Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.Semantic proximity Read ↗

Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.Semantic proximity Read ↗

Expression, Transcription, and Possible Antagonistic Interaction of the Human Nedd4L Gene VariantSemantic proximity Read ↗

NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.Semantic proximity Read ↗

Association of NEDD4L ubiquitin ligase with essential hypertension.Semantic proximity Read ↗

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