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The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes.

Infection and immunity - 1 Jun 2017

Turner Andrew G, Ong Cheryl-Lynn Y, Djoko Karrera Y, West Nicholas P, Davies Mark R, McEwan Alastair G, Walker Mark J

Abstract excerpt

Streptococcus pyogenes (group A Streptococcus [GAS]) is an obligate human pathogen responsible for a broad spectrum of human disease. GAS has a requirement for metal homeostasis within the human host and, as such, tightly modulates metal uptake and efflux during infection. Metal acquisition systems are required to combat metal sequestration by the host, while metal efflux systems are essential to protect against...

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Adenosine Triphosphatases
Homeostasis
Hydrogen Peroxide
Iron
Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidative Stress

Streptococcal Infections

Streptococcus pyogenes

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Identifiers

PMID: 28373352
DOI: 10.1128/IAI.00140-17
PMCID: PMC5442638

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