Article
Distribution and genetic diversity of the ABC transporter lipoproteins PiuA and PiaA within Streptococcus pneumoniae and related streptococci.
Journal of bacteriology - 1 Feb 2006
Whalan Rachael H, Funnell Simon G P, Bowler Lucas D, Hudson Michael J, Robinson Andrew, Dowson Christopher G
Abstract excerpt
Streptococcus pneumoniae is a major cause of morbidity and mortality worldwide. The existence of approximately 90 antigenically distinct capsular serotypes has greatly complicated the development of an effective pneumococcal vaccine. Virulence-associated proteins common and conserved among all capsular types now represent the best strategy to combat pneumococcal infections. PiuA and PiaA are the lipoprotein...
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