Article
Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef.
FEBS letters - 11 May 2001
Geyer M, Peterlin B M
Abstract excerpt
The accessory Nef protein from human and simian immunodeficiency viruses is critical for efficient viral replication and pathogenesis. Here we present an assembly of the full length structure of HIV-1 Nef, allele NL4-3, based on the previously solved anchor and core domain structures. The center part of the 33 residue encompassing flexible loop at the C-terminus of Nef, involved in Nef internalization and CD4...
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