Article
CGH alterations in medullary thyroid carcinomas in relation to the RET M918T mutation and clinical outcome.
International journal of oncology - 1 Jun 2001
Frisk T, Zedenius J, Lundberg J, Wallin G, Kytölä S, Larsson C
Abstract excerpt
Apart from the RET proto-oncogene (RET) no other genes have been found to be involved in medullary thyroid carcinoma (MTC) tumorigenesis. Germline RET mutations are seen virtually in all familial forms of MTC and somatic RET mutations are often detected in sporadic MTC. In sporadic MTCs the RET gene is mutated in codon 918, where a methionine is substituted to a threonine (M918T). In this study 24 MTCs were...
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