Article
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress.
Nature - 19 Sept 2002
Kops Geert J P L, Dansen Tobias B, Polderman Paulien E, Saarloos Ingrid, Wirtz Karel W A, Coffer Paul J, Huang Ting-T, Bos Johannes L, Medema René H, Burgering Boudewijn M T
Abstract excerpt
Reactive oxygen species are required for cell proliferation but can also induce apoptosis. In proliferating cells this paradox is solved by the activation of protein kinase B (PKB; also known as c-Akt), which protects cells from apoptosis. By contrast, it is unknown how quiescent cells that lack PKB activity are protected against cell death induced by reactive oxygen species. Here we show that the PKB-regulated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.